Guidelines International Network– North America and The New York Academy of Medicine -Section on Evidence Based Healthcare recently presented: E-GAPPS IV:COVID-19 and the Challenge to GuidanceA Virtual Conference and Open Space Meeting This virtual event took online on the 23rd and 24th March 2021. It explored the innovative approaches with which clinicians and guideline developers met the urgent need of evidence-informed clinical guidance amidst the chaos that accompanied the surges, and new opportunities for collaboration between the guideline community and healthcare providers in preparation for future global crises. Over 100 registrants took part in the event. Many thanks to the session ignitor, Sandra Zelman Lewis for being part of this session and to Yerado Abrahamian, Mary Nix and Peter Wyer for organising! The event has been described as inspirational and constructive! Recordings from the event are available on our YouTube channel.