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Introduction

This G-I-N award acknowledges an individual’s contribution to innovation in the methodology, development, and /or implementation of clinical practice guidelines.

Najoua Mlika-Cabanne October 2008

Najoua Mlika-Cabanne

 

The Najoua Mlika-Cabanne Innovation Award is named in memory of Najoua Mlika-Cabanne MD PHD, formerly Deputy Head of the Guidelines Department at the Haute Autorité de Santé (HAS, French National Authority for Health), Trustee of the Guidelines International Network between 2003 and 2010, and G-I-N Honorary Patron

Najoua Mlika-Cabanne graduated in medicine from Sousse Medical Faculty in Tunisia in 1982. From a local government post in public health in Tunisia, Najoua moved to clinical research in France first at the Gustave Roussy Cancer Centre and then at INSERM, the French National Institute for Health and Medical Research. After that Najoua became deputy head of the Guidelines Department at the Haute Autorité de Santé (HAS, French National Authority for Health). She was in charge of various aspects of the development of clinical practice guidelines for over 10 years: drafting of guidelines, managing a team of guideline developers, and university teaching, in particular courses on medical statistics, quality management, and assessment of health systems. In her post at HAS, she liaised with experts in a very wide variety of aspects of the development of quality of care and health technology assessment.

From 2000, Najoua was increasingly involved in national and international partnerships. She was on the Committee for the Assessment of National Registers at the French Institute for Public Health Surveillance (InVS), was the mandated HAS representative for several collaborative international projects (for example, CoCanCPG), and was an active member of the International Review Panel of the International Society for Quality in Healthcare (ISQUA), the ADAPTE collaboration, and G-I-N.

Najoua was elected to the G-I-N Board in 2003 and was co-chair of the international Working Group on Evidence Tables. She was also a co-editor of enGINe, the G-I-N newsletter.

During her career Dr Najoua Mlika-Cabanne made a significant contribution to the science of clinical guideline development and consistently fostered international collaboration and friendship.   

 

Previous Award Recipients

Sixth award 2018 - Robin Vernooij


Robin Vernooij

 

 

 

 

 

Fifth award 2017 - Dr Linn Brandt

Linn Brandt2

 

 

 

 

 

 

 

Fourth award 2016 - Richard Rosenfeld and Ilkka Kunnamo

Richard Rosenfeld

Ilkka Kunnamo

 

 

 

 

 

 

 

 

 

 

 

 

Third Award 2015 - Philip van der Wees

 Philip van der Wees

 

 

Second award 2014 - Jeremy Grimshaw

Jeremy Grimshaw

 

 

 First award 2012 - Marcia Kelson

  Marcia Kelson and NMC Award

 

 

David PhillippoDavid Phillippo - 2019 Award Recipient

 

David is early in his career, having only recently completed his MSc in Statistics at the University of Bristol in 2015, after which he took up his current position as Research Associate in Evidence Synthesis, working with the Multiparameter Evidence Synthesis group and the NICE Technical Support Unit. Within this time, he has been thinking innovatively around how we test confidence in recommendations based on network meta-analyses in a guideline development context.

Guideline developers need to assess the robustness of their recommendations to potential limitations in the evidence. However, current frameworks such as GRADE can only examine the quality of the NMA results, and do not take into account the decision context. Intuitively, low quality evidence that has negligible influence on the treatment recommendation should be of little concern, but more influential evidence should be scrutinised carefully and confidence in the robustness of the recommendation may be diminished. David has developed an algebraic approach to threshold analysis, which answers the question, “This evidence may be biased or of low quality, but how much would it have to change before the recommendation changes?” The result is a set of thresholds, within which changes to the evidence have no impact on the recommendation, but beyond the threshold a new recommendation (also output from the method) would be reached. Thresholds can also be obtained to investigate concerns about specific limitations in the evidence, for example a lack of blinding in certain studies. By combining these thresholds with judgements of the plausible magnitude and direction of possible biases or uncertainties in the evidence, the impact (if any) of plausible changes in the evidence is then easily determined, and decision makers can incorporate knowledge of robustness or sensitivity into their recommendations.

The threshold approach has been successfully used in the Specialist Neonatal Respiratory Care guideline on preterm ventilation (currently in development), and further applications in NICE guidelines are planned for later this year. David has developed and maintains a freely-available R package to perform threshold analysis using a simple interface.

Alongside the threshold work David is currently undertaking his PhD, focusing on methods for population-adjusted indirect comparisons and network meta-analyses. He is the lead author on a Technical Support Document published by the NICE Decision Support Unit that examines current population adjustment methods, their properties, assumptions, and limitations, and provides guidelines for their use in NICE Technology Appraisals. This is cited by manufacturers making submissions to NICE and by academic groups critiquing those submissions. He is now developing improved methods for population adjustment that will take network meta-analysis to an entirely new level.

David is an accomplished and exceptionally clear speaker and presenter. He has given invited talks and seminars on his work to academic and industry audiences at international conferences, universities, and companies, as well as NICE guideline development committees, working groups, and the NICE Technical Forum. This level of recognition and engagement is unusual for someone at this stage in their career. David’s work is not only innovative, but impactful.

NMC 2019 Winner

October 2019
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